The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CEP350. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP350 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP350, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,702,681–179,703,716 | 251.6 kb | Distal (>10kb) Multiome | 163 | |
| chr1:179,742,680–179,744,798 | 211.6 kb | Distal (>10kb) Multiome | 322 | |
| chr1:179,788,146–179,788,608 | 166.3 kb | Distal (>10kb) Multiome | 55 | |
| chr1:179,814,386–179,815,656 | 139.8 kb | Distal (>10kb) Multiome | 543 | |
| chr1:179,877,712–179,878,194 | 76.9 kb | Distal (>10kb) Multiome | 604 | |
| chr1:179,881,882–179,883,626 | 72.1 kb | Distal (>10kb) Multiome | 1162 | |
| chr1:179,954,005–179,955,565 | 69 bp | At TSS Multiome | 988 | |
| chr1:180,154,067–180,155,804 | 200.0 kb | Distal (>10kb) Multiome | 774 | |
| chr1:180,167,793–180,168,531 | 213.4 kb | Distal (>10kb) Multiome | 388 | |
| chr1:180,198,090–180,198,743 | 243.6 kb | Distal (>10kb) Multiome | 103 | |
| chr1:180,228,833–180,231,894 | 275.0 kb | Distal (>10kb) Multiome | 657 | |
| chr1:180,234,382–180,235,870 | 280.0 kb | Distal (>10kb) Multiome | 241 |
Genomic view of the CEP350 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.