This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COL4A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COL4A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COL4A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:110,137,769–110,139,050 | 168.7 kb | Distal (>10kb) Multiome | 516 | |
| chr13:110,186,087–110,187,420 | 120.7 kb | Distal (>10kb) Multiome | 95 | |
| chr13:110,296,934–110,297,384 | 9.9 kb | Proximal (<10kb) | 15 | |
| chr13:110,306,322–110,309,108 | 82 bp | At TSS Multiome | 398 | |
| chr13:110,312,518–110,313,013 | 5.3 kb | Proximal (<10kb) | 91 | |
| chr13:110,485,584–110,487,244 | 179.3 kb | Distal (>10kb) Multiome | 272 | |
| chr13:110,540,846–110,542,010 | 234.1 kb | Distal (>10kb) Multiome | 268 | |
| chr13:110,561,007–110,562,237 | 254.5 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the COL4A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.