The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for PDE10A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE10A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE10A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:165,458,199–165,458,682 | 202.7 kb | Distal (>10kb) Multiome HiCAR | 103 | |
| chr6:165,573,768–165,574,476 | 87.1 kb | Distal (>10kb) Multiome | 275 | |
| chr6:165,656,497–165,656,979 | 5.6 kb | Proximal (<10kb) | 17 | |
| chr6:165,657,089–165,657,293 | 5.3 kb | Proximal (<10kb) | 39 | |
| chr6:165,660,121–165,664,789 | 1.7 kb | Proximal (<10kb) Multiome | 535 | |
| chr6:165,668,762–165,669,657 | 6.2 kb | Proximal (<10kb) | 42 | |
| chr6:165,884,869–165,885,717 | 224.2 kb | Distal (>10kb) Multiome | 420 | |
| chr6:165,956,717–165,957,473 | 296.0 kb | Distal (>10kb) Multiome | 102 | |
| chr6:165,987,038–165,987,302 | 814 bp | At TSS | 211 | |
| chr6:165,987,614–165,989,074 | 327.4 kb | Distal (>10kb) Multiome | 382 | |
| chr6:166,040,358–166,040,865 | 379.5 kb | Distal (>10kb) Multiome | 85 | |
| chr6:166,097,427–166,098,419 | 436.9 kb | Distal (>10kb) Multiome | 280 | |
| chr6:166,166,366–166,169,959 | 506.9 kb | Distal (>10kb) Multiome | 361 | |
| chr6:166,194,896–166,195,965 | 534.3 kb | Distal (>10kb) Multiome | 171 | |
| chr6:166,204,810–166,205,524 | 544.0 kb | Distal (>10kb) Multiome | 164 | |
| chr6:166,252,782–166,254,328 | 592.4 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the PDE10A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.