This gene encodes a subunit of the intraflagellar transport complex A (IFT-A). IFT-A is a multiprotein complex that plays an important role in cilia assembly and maintenance by mediating retrograde ciliary transport. Mutations in this gene are a cause of cranioectodermal dysplasia-3 (CED3), also known as Sensenbrenner syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for IFT43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IFT43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IFT43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:75,660,453–75,661,746 | 324.7 kb | Distal (>10kb) Multiome HiCAR | 786 | |
| chr14:75,711,559–75,712,330 | 273.7 kb | Distal (>10kb) Multiome HiCAR | 434 | |
| chr14:75,972,579–75,973,063 | 13.0 kb | Distal (>10kb) Multiome | 56 | |
| chr14:75,982,219–75,983,158 | 3.2 kb | Proximal (<10kb) Multiome | 459 | |
| chr14:75,985,670–75,986,242 | 112 bp | At TSS Multiome | 373 | |
| chr14:76,136,532–76,137,578 | 151.3 kb | Distal (>10kb) Multiome | 100 | |
| chr14:76,138,216–76,139,123 | 153.0 kb | Distal (>10kb) Multiome | 309 | |
| chr14:76,151,503–76,152,617 | 166.1 kb | Distal (>10kb) Multiome | 754 |
Genomic view of the IFT43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.