Transcription factors with Perturb-seq knockdown data for KRCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KRCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KRCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:88,015,193–88,017,502 | 39.0 kb | Distal (>10kb) Multiome | 1123 | |
| chr2:88,054,455–88,054,647 | 1.1 kb | Proximal (<10kb) | 123 | |
| chr2:88,055,077–88,056,028 | 14 bp | At TSS Multiome | 869 | |
| chr2:88,060,442–88,060,865 | 4.7 kb | Proximal (<10kb) | 238 | |
| chr2:88,170,010–88,170,891 | 114.6 kb | Distal (>10kb) Multiome HiCAR | 211 | |
| chr2:88,254,337–88,255,161 | 199.0 kb | Distal (>10kb) Multiome | 121 | |
| chr2:88,329,732–88,330,828 | 274.6 kb | Distal (>10kb) Multiome | 408 | |
| chr2:88,350,256–88,351,496 | 295.3 kb | Distal (>10kb) Multiome | 374 |
Genomic view of the KRCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.