This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for CDON. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDON upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDON, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:125,886,970–125,888,478 | 175.1 kb | Distal (>10kb) Multiome | 823 | |
| chr11:125,902,922–125,903,413 | 159.7 kb | Distal (>10kb) Multiome | 495 | |
| chr11:125,904,107–125,904,760 | 158.4 kb | Distal (>10kb) Multiome | 235 | |
| chr11:125,938,819–125,939,449 | 123.8 kb | Distal (>10kb) Multiome | 161 | |
| chr11:125,941,709–125,942,323 | 120.7 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr11:126,061,736–126,063,712 | 229 bp | At TSS Multiome | 802 | |
| chr11:126,082,403–126,083,132 | 19.8 kb | Distal (>10kb) Multiome | 134 | |
| chr11:126,104,267–126,104,892 | 41.7 kb | Distal (>10kb) Multiome HiCAR | 192 | |
| chr11:126,159,698–126,160,582 | 97.2 kb | Distal (>10kb) Multiome | 281 | |
| chr11:126,210,869–126,212,282 | 148.8 kb | Distal (>10kb) Multiome | 846 | |
| chr11:126,268,478–126,269,613 | 206.2 kb | Distal (>10kb) Multiome | 828 | |
| chr11:126,282,310–126,283,787 | 220.2 kb | Distal (>10kb) Multiome | 754 | |
| chr11:126,303,694–126,304,639 | 241.2 kb | Distal (>10kb) Multiome | 979 | |
| chr11:126,345,823–126,346,956 | 283.5 kb | Distal (>10kb) Multiome | 446 | |
| chr11:126,355,100–126,356,405 | 292.8 kb | Distal (>10kb) Multiome | 596 |
Genomic view of the CDON locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.