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DE-1.40

Submodule 12 genes

Mitochondrial respiration and inner membrane organization

This 12-gene module includes IMPDH2, UXT, EIF6, NDUFS2, and NDUFS3, with enrichment for mitochondrial inner membrane components and aerobic respiration processes. No transcription factor knockdown data are available for this module, so its regulatory control during ESC-to-DE differentiation cannot be determined from the current dataset.

Key terms: aerobic respiration cellular respiration respiratory electron transport chain ATP synthesis coupled electron transport Notable genes: IMPDH2 UXT EIF6 NDUFS2 NDUFS3 TUFM UQCRC1 MTX1

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z
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