UQCRC1
ubiquinol-cytochrome c reductase core protein 1 | D3S3191, QCR1, UQCR1

Enables ubiquitin protein ligase binding activity. Predicted to be involved in oxidative phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial inner membrane. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1 DE-1.40
Biological processes 24 terms
aerobic respiration (GO:0009060)cellular respiration (GO:0045333)metal ion binding (GO:0046872)mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial processing peptidase complex (GO:0017087)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)oxidative phosphorylation (GO:0006119)protein binding (GO:0005515)protein localization to mitochondrion (GO:0070585)protein-containing complex binding (GO:0044877)proton transmembrane transport (GO:1902600)quinol-cytochrome-c reductase activity (GO:0008121)respiratory chain complex (GO:0098803)respiratory chain complex III (GO:0045275)response to activity (GO:0014823)response to alkaloid (GO:0043279)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
UQCRC1 — as a Regulated Gene

TFs regulating UQCRC1 0 TFs

Transcription factors with Perturb-seq knockdown data for UQCRC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UQCRC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to UQCRC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UQCRC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr3:48,372,864–48,373,543 236.4 kb Distal (>10kb) Multiome 49
chr3:48,428,528–48,430,504 179.6 kb Distal (>10kb) Multiome 910
chr3:48,439,801–48,440,548 169.5 kb Distal (>10kb) Multiome 787
chr3:48,446,396–48,447,180 162.9 kb Distal (>10kb) Multiome 767
chr3:48,465,344–48,466,310 143.9 kb Distal (>10kb) Multiome 670
chr3:48,472,636–48,473,658 136.4 kb Distal (>10kb) Multiome 821
chr3:48,503,451–48,504,839 105.6 kb Distal (>10kb) Multiome 419
chr3:48,556,022–48,557,666 52.6 kb Distal (>10kb) Multiome 794
chr3:48,558,131–48,558,793 51.3 kb Distal (>10kb) Multiome 503
chr3:48,608,816–48,610,628 46 bp At TSS Multiome 850
chr3:48,634,696–48,636,251 25.9 kb Distal (>10kb) Multiome 898
chr3:48,655,787–48,657,257 46.8 kb Distal (>10kb) Multiome 438
chr3:48,661,275–48,664,636 52.0 kb Distal (>10kb) Multiome 1248
chr3:48,685,362–48,686,531 76.2 kb Distal (>10kb) Multiome 770
chr3:48,716,958–48,717,863 107.7 kb Distal (>10kb) Multiome 634
chr3:48,847,059–48,848,224 238.1 kb Distal (>10kb) Multiome 772
chr3:48,898,423–48,899,110 289.2 kb Distal (>10kb) Multiome 739

Genome Browser

Genomic view of the UQCRC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr3:48,362,864 – 48,909,110
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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