This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for IMPDH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IMPDH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IMPDH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,847,059–48,848,224 | 181.6 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 130.5 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 110.6 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 39.4 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 24.9 kb | Distal (>10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 21.5 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 10.9 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 7.6 kb | Proximal (<10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 5 bp | At TSS Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 64.9 kb | Distal (>10kb) Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 75.4 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 91.5 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 104.3 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 136.9 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 142.0 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 247.7 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,468,926–49,470,930 | 440.8 kb | Distal (>10kb) Multiome HiCAR | 919 |
Genomic view of the IMPDH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.