DE-1

DE-1.27

Submodule 17 genes

Autophagy and vesicle trafficking pathway

This module contains 17 genes including GABARAPL2, RAC3, PTP4A2, COX17, and BZW1, with enrichment in autophagy and vesicle-mediated transport processes. Knockdown of SOX17 activates this module.

Notable genes: GABARAPL2 RAC3 PTP4A2 COX17 BZW1 LSM10 VBP1 MICOS13 Top TFs: SOX17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (17)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z