The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for PTP4A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTP4A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTP4A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:31,644,333–31,645,606 | 293.4 kb | Distal (>10kb) Multiome | 926 | |
| chr1:31,647,107–31,647,947 | 290.7 kb | Distal (>10kb) Multiome | 49 | |
| chr1:31,703,931–31,704,503 | 234.2 kb | Distal (>10kb) Multiome | 217 | |
| chr1:31,714,302–31,716,109 | 223.1 kb | Distal (>10kb) Multiome | 759 | |
| chr1:31,760,521–31,761,442 | 177.4 kb | Distal (>10kb) Multiome | 317 | |
| chr1:31,762,648–31,763,343 | 175.6 kb | Distal (>10kb) Multiome | 402 | |
| chr1:31,764,083–31,764,672 | 174.0 kb | Distal (>10kb) Multiome | 263 | |
| chr1:31,769,677–31,770,397 | 168.2 kb | Distal (>10kb) Multiome | 185 | |
| chr1:31,776,109–31,776,832 | 161.8 kb | Distal (>10kb) Multiome | 86 | |
| chr1:31,788,126–31,789,694 | 149.7 kb | Distal (>10kb) Multiome | 713 | |
| chr1:31,815,736–31,816,251 | 122.3 kb | Distal (>10kb) Multiome HiCAR | 666 | |
| chr1:31,937,587–31,938,944 | 127 bp | At TSS Multiome | 1111 | |
| chr1:31,943,994–31,945,090 | 6.2 kb | Proximal (<10kb) Multiome | 826 | |
| chr1:31,954,721–31,955,545 | 16.8 kb | Distal (>10kb) Multiome | 628 | |
| chr1:31,964,141–31,964,595 | 25.9 kb | Distal (>10kb) Multiome | 529 | |
| chr1:32,013,168–32,015,085 | 75.3 kb | Distal (>10kb) Multiome | 988 | |
| chr1:32,072,319–32,073,738 | 134.8 kb | Distal (>10kb) Multiome | 909 | |
| chr1:32,107,881–32,108,706 | 169.7 kb | Distal (>10kb) Multiome | 779 | |
| chr1:32,179,263–32,180,190 | 241.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 262.3 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 267.2 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 284.0 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the PTP4A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.