Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for COX17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = COX17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of COX17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:119,417,868–119,418,544 | 259.1 kb | Distal (>10kb) Multiome | 156 | |
| chr3:119,463,124–119,464,243 | 213.7 kb | Distal (>10kb) Multiome | 902 | |
| chr3:119,468,550–119,469,486 | 208.4 kb | Distal (>10kb) Multiome | 832 | |
| chr3:119,497,916–119,499,024 | 178.9 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr3:119,579,336–119,580,732 | 97.5 kb | Distal (>10kb) Multiome | 519 | |
| chr3:119,676,820–119,677,853 | 61 bp | At TSS Multiome | 778 | |
| chr3:119,679,960–119,680,195 | 2.6 kb | Proximal (<10kb) | 73 | |
| chr3:119,702,500–119,703,521 | 25.6 kb | Distal (>10kb) Multiome | 399 |
Genomic view of the COX17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.