GABARAPL2

GABA type A receptor associated protein like 2 | ATG8, ATG8C, GATE-16, GATE16, GEF2

Enables phosphatidylethanolamine binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of proteasomal protein catabolic process and protein localization to endoplasmic reticulum. Located in Golgi membrane and autophagosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.27

Biological processes 37 terms

ATPase binding (GO:0051117)GABA receptor binding (GO:0050811)GABA receptor binding (GO:0050811)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)SNARE binding (GO:0000149)autophagosome (GO:0005776)autophagosome (GO:0005776)autophagosome assembly (GO:0000045)autophagosome assembly (GO:0000045)autophagosome maturation (GO:0097352)autophagosome membrane (GO:0000421)autophagosome membrane (GO:0000421)autophagosome membrane (GO:0000421)autophagy (GO:0006914)beta-tubulin binding (GO:0048487)cellular response to nitrogen starvation (GO:0006995)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)intra-Golgi vesicle-mediated transport (GO:0006891)microtubule binding (GO:0008017)mitophagy (GO:0000423)negative regulation of proteasomal protein catabolic process (GO:1901799)phosphatidylethanolamine binding (GO:0008429)phosphatidylethanolamine binding (GO:0008429)phospholipid binding (GO:0005543)positive regulation of ATP-dependent activity (GO:0032781)protein binding (GO:0005515)protein localization to endoplasmic reticulum (GO:0070972)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)ubiquitin protein ligase binding (GO:0031625)

Expression (TPM)

TFs regulating GABARAPL2 0 TFs

Transcription factors with Perturb-seq knockdown data for GABARAPL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GABARAPL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GABARAPL2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GABARAPL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:75,265,114–75,266,526	300.3 kb	Distal (>10kb) Multiome	798
chr16:75,432,825–75,434,426	132.8 kb	Distal (>10kb) Multiome	1143
chr16:75,463,598–75,465,197	101.7 kb	Distal (>10kb) Multiome	999
chr16:75,494,705–75,495,929	70.9 kb	Distal (>10kb) Multiome	341
chr16:75,516,521–75,518,019	49.0 kb	Distal (>10kb) Multiome	921
chr16:75,555,188–75,556,662	11.1 kb	Distal (>10kb) Multiome	900
chr16:75,565,173–75,565,338	1.0 kb	Proximal (<10kb)	364
chr16:75,565,779–75,567,123	60 bp	At TSS Multiome	834
chr16:75,593,861–75,594,383	27.8 kb	Distal (>10kb) Multiome	336
chr16:75,622,804–75,623,690	56.9 kb	Distal (>10kb) Multiome	852
chr16:75,647,337–75,649,003	82.5 kb	Distal (>10kb) Multiome	1002
chr16:77,190,160–77,191,630	1624.5 kb	Distal (>10kb) Multiome HiCAR	915
chr16:77,211,464–77,213,653	1646.0 kb	Distal (>10kb) Multiome HiCAR	644

Genome Browser

Genomic view of the GABARAPL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.