RNA-seq expression profiles of FOXA2 and SOX17 across the ESC → Definitive Endoderm time course, showing whether the TF and its putative target are co-expressed.
Distribution of per-gene regression coefficients for each FOXA2 guide RNA in the Perturb-seq DE screen. The marker shows where SOX17 falls in each distribution, indicating the direction and magnitude of its response to FOXA2 knockdown.
Regulatory elements (ATAC-seq peaks) linking FOXA2 to SOX17, supported by TOBIAS motif footprints and/or ChIP-seq peak overlap. The diagram connects each binding source through intermediate elements to the target gene — click any pill to filter the view.
Genomic view centered on regulatory elements linking FOXA2 to SOX17. Tracks include TF binding peaks (motif footprints and ChIP-seq), ATAC-seq accessibility, RNA-seq expression, and arc-loop connections from each element to the SOX17 TSS — all across the ESC → DE time course.