Predicted to enable zinc ion binding activity. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSWIM5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSWIM5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSWIM5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:44,986,311–44,986,894 | 220.0 kb | Distal (>10kb) Multiome | 979 | |
| chr1:45,010,856–45,013,180 | 194.4 kb | Distal (>10kb) Multiome | 909 | |
| chr1:45,205,664–45,207,097 | 105 bp | At TSS Multiome | 691 | |
| chr1:45,216,712–45,217,234 | 10.4 kb | Distal (>10kb) Multiome | 42 | |
| chr1:45,303,203–45,304,881 | 97.2 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:45,315,837–45,316,870 | 109.5 kb | Distal (>10kb) Multiome | 113 | |
| chr1:45,317,165–45,317,643 | 110.8 kb | Distal (>10kb) Multiome | 7 | |
| chr1:45,321,623–45,322,180 | 115.2 kb | Distal (>10kb) Multiome | 54 | |
| chr1:45,326,327–45,328,092 | 120.3 kb | Distal (>10kb) Multiome | 382 | |
| chr1:45,339,505–45,340,694 | 133.5 kb | Distal (>10kb) Multiome | 951 | |
| chr1:45,490,605–45,491,773 | 284.7 kb | Distal (>10kb) Multiome | 900 | |
| chr1:45,499,499–45,500,620 | 293.6 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the ZSWIM5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.