Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF721. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF721 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF721, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:212,417–212,910 | 261.5 kb | Distal (>10kb) Multiome | 155 | |
| chr4:304,967–305,746 | 168.6 kb | Distal (>10kb) Multiome | 151 | |
| chr4:336,352–338,341 | 136.5 kb | Distal (>10kb) Multiome | 493 | |
| chr4:473,613–474,432 | 41 bp | At TSS Multiome | 745 | |
| chr4:498,731–499,543 | 25.1 kb | Distal (>10kb) Multiome | 869 | |
| chr4:575,294–576,132 | 101.3 kb | Distal (>10kb) Multiome | 154 | |
| chr4:663,207–664,324 | 189.6 kb | Distal (>10kb) Multiome | 298 | |
| chr4:673,501–675,336 | 200.3 kb | Distal (>10kb) Multiome | 920 | |
| chr4:680,919–681,550 | 207.3 kb | Distal (>10kb) Multiome | 275 | |
| chr4:688,280–689,636 | 215.2 kb | Distal (>10kb) Multiome | 218 | |
| chr4:705,313–706,398 | 231.6 kb | Distal (>10kb) Multiome | 613 |
Genomic view of the ZNF721 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.