This gene encodes a zinc finger protein containing a Kruppel-associated box (KRAB) domain at its N-terminus, followed by contiguous C2H2 zinc finger motifs. The encoded protein is a nuclear protein that can act as a transcriptional repressor of growth factor-mediated signaling pathways in a reporter gene assay. This protein has been shown to interact with the SRY-box 9 gene product, and suppresses its transcriptional activity by inhibiting its DNA binding activity. Reduced expression of this gene promotes chondrocyte differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ZNF606. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF606 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF606, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,708,682–57,709,450 | 293.6 kb | Distal (>10kb) Multiome | 199 | |
| chr19:57,727,326–57,727,941 | 275.2 kb | Distal (>10kb) Multiome | 400 | |
| chr19:57,746,610–57,747,111 | 256.0 kb | Distal (>10kb) Multiome | 625 | |
| chr19:57,769,422–57,770,058 | 233.1 kb | Distal (>10kb) Multiome | 509 | |
| chr19:57,803,547–57,804,316 | 198.9 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 197.7 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 192.0 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 187.8 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 183.2 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 172.5 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 153.0 kb | Distal (>10kb) Multiome | 291 | |
| chr19:57,887,264–57,887,897 | 115.2 kb | Distal (>10kb) Multiome | 47 | |
| chr19:57,888,389–57,889,457 | 113.7 kb | Distal (>10kb) Multiome | 322 | |
| chr19:57,916,199–57,917,124 | 86.1 kb | Distal (>10kb) Multiome | 535 | |
| chr19:57,934,907–57,935,617 | 67.4 kb | Distal (>10kb) Multiome | 259 | |
| chr19:57,947,388–57,948,012 | 55.0 kb | Distal (>10kb) Multiome | 675 | |
| chr19:57,992,827–57,993,140 | 9.7 kb | Proximal (<10kb) | 16 | |
| chr19:58,002,336–58,003,368 | 32 bp | At TSS Multiome | 830 | |
| chr19:58,059,066–58,059,937 | 56.6 kb | Distal (>10kb) Multiome | 284 | |
| chr19:58,097,783–58,098,870 | 95.5 kb | Distal (>10kb) Multiome | 458 | |
| chr19:58,150,278–58,150,941 | 147.9 kb | Distal (>10kb) Multiome | 533 | |
| chr19:58,154,448–58,155,527 | 152.3 kb | Distal (>10kb) Multiome | 802 | |
| chr19:58,182,544–58,183,906 | 180.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr19:58,228,362–58,229,199 | 226.1 kb | Distal (>10kb) Multiome | 706 | |
| chr19:58,278,271–58,279,774 | 276.0 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the ZNF606 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.