This gene encodes a protein containing DBF4-type zinc finger domains. This gene is imprinted and paternally expressed in lymphocytes but is more stochastically expressed in the placenta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for ZDBF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDBF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDBF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:206,032,139–206,032,814 | 242.2 kb | Distal (>10kb) Multiome | 47 | |
| chr2:206,079,507–206,080,446 | 194.7 kb | Distal (>10kb) Multiome | 153 | |
| chr2:206,082,237–206,082,708 | 192.2 kb | Distal (>10kb) Multiome | 71 | |
| chr2:206,083,576–206,086,328 | 188.6 kb | Distal (>10kb) Multiome | 990 | |
| chr2:206,158,932–206,160,379 | 115.1 kb | Distal (>10kb) Multiome | 968 | |
| chr2:206,212,416–206,212,901 | 62.0 kb | Distal (>10kb) Multiome | 120 | |
| chr2:206,274,456–206,275,776 | 184 bp | At TSS Multiome | 641 | |
| chr2:206,442,772–206,444,455 | 168.9 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the ZDBF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.