Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:32,179,263–32,180,190 | 285.3 kb | Distal (>10kb) Multiome | 1019 | |
| chr1:32,200,233–32,201,756 | 264.4 kb | Distal (>10kb) Multiome | 573 | |
| chr1:32,204,985–32,206,258 | 259.5 kb | Distal (>10kb) Multiome | 679 | |
| chr1:32,221,877–32,222,889 | 242.7 kb | Distal (>10kb) Multiome | 755 | |
| chr1:32,239,728–32,240,979 | 224.7 kb | Distal (>10kb) Multiome | 456 | |
| chr1:32,248,081–32,248,895 | 216.6 kb | Distal (>10kb) Multiome | 622 | |
| chr1:32,291,710–32,292,726 | 173.0 kb | Distal (>10kb) Multiome | 900 | |
| chr1:32,334,713–32,336,836 | 128.8 kb | Distal (>10kb) Multiome | 804 | |
| chr1:32,351,055–32,352,355 | 113.6 kb | Distal (>10kb) Multiome | 944 | |
| chr1:32,361,365–32,362,459 | 102.9 kb | Distal (>10kb) Multiome | 305 | |
| chr1:32,393,928–32,395,356 | 70.5 kb | Distal (>10kb) Multiome | 930 | |
| chr1:32,437,702–32,438,502 | 26.8 kb | Distal (>10kb) Multiome | 85 | |
| chr1:32,439,697–32,440,223 | 25.2 kb | Distal (>10kb) Multiome | 40 | |
| chr1:32,454,771–32,455,103 | 10.0 kb | Proximal (<10kb) | 118 | |
| chr1:32,464,697–32,465,552 | 29 bp | At TSS Multiome | 408 | |
| chr1:32,500,363–32,501,049 | 35.7 kb | Distal (>10kb) Multiome | 540 | |
| chr1:32,520,498–32,520,989 | 55.6 kb | Distal (>10kb) Multiome | 384 | |
| chr1:32,539,285–32,540,081 | 74.7 kb | Distal (>10kb) Multiome | 434 | |
| chr1:32,540,505–32,541,033 | 75.8 kb | Distal (>10kb) Multiome | 172 | |
| chr1:32,611,983–32,612,668 | 147.2 kb | Distal (>10kb) Multiome | 560 | |
| chr1:32,643,807–32,644,727 | 179.1 kb | Distal (>10kb) Multiome | 70 | |
| chr1:32,650,248–32,651,874 | 186.0 kb | Distal (>10kb) Multiome | 1164 | |
| chr1:32,712,054–32,712,688 | 247.3 kb | Distal (>10kb) Multiome | 645 | |
| chr1:32,715,926–32,717,303 | 251.7 kb | Distal (>10kb) Multiome | 551 | |
| chr1:32,736,558–32,737,765 | 272.0 kb | Distal (>10kb) Multiome | 507 | |
| chr1:32,753,606–32,755,507 | 288.9 kb | Distal (>10kb) Multiome | 565 | |
| chr1:32,758,502–32,759,280 | 293.8 kb | Distal (>10kb) Multiome | 144 |
Genomic view of the ZBTB8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.