This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for YWHAH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,661,894–31,662,649 | 282.3 kb | Distal (>10kb) Multiome HiCAR | 791 | |
| chr22:31,676,686–31,677,164 | 267.7 kb | Distal (>10kb) Multiome | 294 | |
| chr22:31,749,600–31,750,546 | 194.4 kb | Distal (>10kb) Multiome | 850 | |
| chr22:31,752,977–31,754,325 | 190.6 kb | Distal (>10kb) Multiome | 854 | |
| chr22:31,943,414–31,945,454 | 163 bp | At TSS Multiome | 807 | |
| chr22:31,969,969–31,971,124 | 26.1 kb | Distal (>10kb) Multiome | 601 | |
| chr22:32,139,785–32,140,267 | 195.5 kb | Distal (>10kb) Multiome | 14 | |
| chr22:32,147,169–32,147,709 | 202.9 kb | Distal (>10kb) Multiome | 106 | |
| chr22:32,175,754–32,176,273 | 231.5 kb | Distal (>10kb) Multiome | 106 | |
| chr22:32,202,214–32,203,260 | 258.0 kb | Distal (>10kb) Multiome | 251 | |
| chr22:32,204,184–32,205,469 | 260.5 kb | Distal (>10kb) Multiome | 338 | |
| chr22:32,206,463–32,207,219 | 262.4 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the YWHAH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.