The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for XYLB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XYLB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XYLB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:38,136,419–38,139,307 | 208.0 kb | Distal (>10kb) Multiome HiCAR | 989 | |
| chr3:38,164,619–38,166,160 | 181.5 kb | Distal (>10kb) Multiome HiCAR | 1040 | |
| chr3:38,345,594–38,347,388 | 34 bp | At TSS Multiome | 971 | |
| chr3:38,452,852–38,456,220 | 106.9 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr3:38,495,771–38,496,881 | 149.6 kb | Distal (>10kb) Multiome HiCAR | 764 | |
| chr3:38,580,074–38,580,574 | 233.6 kb | Distal (>10kb) Multiome | 109 | |
| chr3:38,601,761–38,602,426 | 255.3 kb | Distal (>10kb) Multiome | 48 | |
| chr3:38,640,708–38,641,494 | 294.3 kb | Distal (>10kb) Multiome | 182 |
Genomic view of the XYLB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.