The protein encoded by this gene is an androgen receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Transcription factors with Perturb-seq knockdown data for WDR77. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR77 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR77, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:111,203,689–111,204,663 | 244.9 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr1:111,219,041–111,220,185 | 229.6 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr1:111,304,989–111,305,695 | 143.9 kb | Distal (>10kb) Multiome | 89 | |
| chr1:111,346,093–111,347,079 | 102.8 kb | Distal (>10kb) Multiome | 541 | |
| chr1:111,448,546–111,449,931 | 70 bp | At TSS Multiome | 782 | |
| chr1:111,507,573–111,508,705 | 58.9 kb | Distal (>10kb) Multiome | 791 | |
| chr1:111,515,518–111,516,406 | 66.9 kb | Distal (>10kb) Multiome | 240 | |
| chr1:111,617,926–111,618,510 | 169.0 kb | Distal (>10kb) Multiome | 90 | |
| chr1:111,619,191–111,620,837 | 170.5 kb | Distal (>10kb) Multiome | 640 | |
| chr1:111,639,680–111,640,200 | 190.7 kb | Distal (>10kb) Multiome | 183 | |
| chr1:111,738,257–111,740,696 | 291.2 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the WDR77 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.