This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:120,644,648–120,645,329 | 206.4 kb | Distal (>10kb) Multiome | 35 | |
| chr10:120,738,690–120,739,443 | 112.4 kb | Distal (>10kb) Multiome | 85 | |
| chr10:120,850,937–120,851,659 | 61 bp | At TSS Multiome | 1009 | |
| chr10:120,948,941–120,949,508 | 97.7 kb | Distal (>10kb) Multiome | 424 | |
| chr10:120,979,285–120,980,093 | 128.3 kb | Distal (>10kb) Multiome | 342 | |
| chr10:120,981,508–120,982,509 | 130.6 kb | Distal (>10kb) Multiome | 187 | |
| chr10:121,002,715–121,003,391 | 151.7 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the WDR11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.