The protein encoded by this gene contains a WW domain, which is a protein module found in a wide range of signaling proteins. This domain mediates protein-protein interactions and binds proteins containing short linear peptide motifs that are proline-rich or contain at least one proline. This gene product shares 94% sequence identity with the WAC protein in mouse, however, its exact function is not known. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Transcription factors with Perturb-seq knockdown data for WAC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WAC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WAC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:28,293,436–28,294,074 | 239.3 kb | Distal (>10kb) Multiome | 102 | |
| chr10:28,302,152–28,303,596 | 230.0 kb | Distal (>10kb) Multiome | 714 | |
| chr10:28,459,483–28,460,059 | 73.3 kb | Distal (>10kb) Multiome | 45 | |
| chr10:28,518,834–28,519,331 | 14.1 kb | Distal (>10kb) Multiome | 47 | |
| chr10:28,532,042–28,534,170 | 268 bp | At TSS Multiome | 975 | |
| chr10:28,668,533–28,669,159 | 135.7 kb | Distal (>10kb) Multiome | 364 | |
| chr10:28,676,409–28,678,520 | 144.3 kb | Distal (>10kb) Multiome | 900 | |
| chr10:28,686,833–28,687,591 | 154.2 kb | Distal (>10kb) Multiome | 104 | |
| chr10:28,722,058–28,722,781 | 189.4 kb | Distal (>10kb) Multiome | 386 | |
| chr10:28,774,446–28,775,116 | 241.6 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the WAC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.