Involved in Golgi to plasma membrane transport and endocytic recycling. Located in endosome. Implicated in Ritscher-Schinzel syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VPS35L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VPS35L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VPS35L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:19,299,373–19,300,029 | 255.9 kb | Distal (>10kb) Multiome | 136 | |
| chr16:19,348,618–19,349,340 | 206.7 kb | Distal (>10kb) Multiome | 189 | |
| chr16:19,410,445–19,411,161 | 144.9 kb | Distal (>10kb) Multiome | 362 | |
| chr16:19,487,848–19,488,641 | 67.5 kb | Distal (>10kb) Multiome | 340 | |
| chr16:19,521,532–19,522,649 | 33.6 kb | Distal (>10kb) Multiome | 825 | |
| chr16:19,523,702–19,524,351 | 31.8 kb | Distal (>10kb) Multiome | 765 | |
| chr16:19,555,060–19,556,522 | 206 bp | At TSS Multiome | 1001 | |
| chr16:19,717,856–19,718,929 | 162.6 kb | Distal (>10kb) Multiome | 935 | |
| chr16:19,722,929–19,723,622 | 167.5 kb | Distal (>10kb) Multiome | 66 | |
| chr16:19,853,872–19,854,881 | 298.7 kb | Distal (>10kb) Multiome | 59 | |
| chr16:19,884,718–19,885,614 | 329.3 kb | Distal (>10kb) Multiome HiCAR | 352 | |
| chr16:20,385,854–20,386,589 | 830.5 kb | Distal (>10kb) Multiome HiCAR | 468 |
Genomic view of the VPS35L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.