Enables GTPase activator activity and small GTPase binding activity. Involved in several processes, including plasma membrane to endosome transport; positive regulation of GTPase activity; and retrograde transport, plasma membrane to Golgi. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP6NL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP6NL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP6NL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:11,603,028–11,603,310 | 8.3 kb | Proximal (<10kb) | 414 | |
| chr10:11,610,860–11,612,125 | 52 bp | At TSS Multiome | 748 | |
| chr10:11,741,667–11,743,276 | 130.8 kb | Distal (>10kb) Multiome | 482 | |
| chr10:11,799,285–11,799,933 | 187.9 kb | Distal (>10kb) Multiome | 102 | |
| chr10:11,823,198–11,824,010 | 211.8 kb | Distal (>10kb) Multiome | 551 | |
| chr10:11,869,855–11,870,414 | 258.6 kb | Distal (>10kb) Multiome | 105 | |
| chr10:11,874,348–11,875,590 | 263.3 kb | Distal (>10kb) Multiome | 672 |
Genomic view of the USP6NL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.