USP37
ubiquitin specific peptidase 37 | KIAA1594

Enables cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; protein deubiquitination; and regulation of DNA replication. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-6 DE-6.14 Developmental clusters: GC5
Biological processes 23 terms
G1/S transition of mitotic cell cycle (GO:0000082)G1/S transition of mitotic cell cycle (GO:0000082)chromosome (GO:0005694)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type deubiquitinase activity (GO:0004843)cysteine-type endopeptidase activity (GO:0004197)cytosol (GO:0005829)deubiquitinase activity (GO:0101005)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein K11-linked deubiquitination (GO:0035871)protein K48-linked deubiquitination (GO:0071108)protein binding (GO:0005515)protein deubiquitination (GO:0016579)protein deubiquitination (GO:0016579)protein deubiquitination (GO:0016579)protein kinase binding (GO:0019901)regulation of DNA replication (GO:0006275)regulation of protein stability (GO:0031647)
Expression (TPM)
USP37 — as a Regulated Gene

TFs regulating USP37 0 TFs

Transcription factors with Perturb-seq knockdown data for USP37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to USP37

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:218,269,385–218,270,929 298.0 kb Distal (>10kb) Multiome 913
chr2:218,290,037–218,290,611 278.0 kb Distal (>10kb) Multiome 264
chr2:218,291,910–218,292,722 275.8 kb Distal (>10kb) Multiome 695
chr2:218,322,154–218,324,454 245.1 kb Distal (>10kb) Multiome 914
chr2:218,367,421–218,368,194 200.5 kb Distal (>10kb) Multiome 450
chr2:218,387,091–218,388,220 180.4 kb Distal (>10kb) Multiome 514
chr2:218,395,568–218,397,399 172.1 kb Distal (>10kb) Multiome 1048
chr2:218,397,484–218,401,433 170.3 kb Distal (>10kb) Multiome 1114
chr2:218,405,424–218,407,478 161.9 kb Distal (>10kb) Multiome 1093
chr2:218,567,787–218,569,400 189 bp At TSS Multiome 1083
chr2:218,569,571–218,569,873 1.2 kb Proximal (<10kb) 106
chr2:218,658,668–218,660,011 91.3 kb Distal (>10kb) Multiome 870
chr2:218,671,689–218,672,558 103.7 kb Distal (>10kb) Multiome 794
chr2:218,710,272–218,711,420 142.5 kb Distal (>10kb) Multiome 957
chr2:218,781,682–218,782,718 213.8 kb Distal (>10kb) Multiome 674
chr2:218,798,810–218,799,640 230.9 kb Distal (>10kb) Multiome 163
chr2:218,799,866–218,800,388 232.0 kb Distal (>10kb) Multiome 82
chr2:218,860,491–218,861,382 292.7 kb Distal (>10kb) Multiome 241

Genome Browser

Genomic view of the USP37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:218,259,385 – 218,871,382
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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