Enables cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Involved in protein deubiquitination. Located in cytoplasm; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for USP12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:26,896,922–26,897,986 | 274.4 kb | Distal (>10kb) Multiome | 120 | |
| chr13:27,170,635–27,172,412 | 130 bp | At TSS Multiome | 737 | |
| chr13:27,175,125–27,175,369 | 3.4 kb | Proximal (<10kb) | 29 | |
| chr13:27,251,189–27,251,961 | 79.6 kb | Distal (>10kb) Multiome | 890 | |
| chr13:27,270,323–27,271,477 | 99.1 kb | Distal (>10kb) Multiome | 687 | |
| chr13:27,361,835–27,362,747 | 190.4 kb | Distal (>10kb) Multiome | 476 | |
| chr13:27,424,036–27,425,195 | 252.8 kb | Distal (>10kb) Multiome | 868 | |
| chr13:27,449,915–27,451,120 | 278.5 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the USP12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.