This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]
Transcription factors with Perturb-seq knockdown data for UNC45A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNC45A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNC45A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,716,853–90,717,827 | 218.0 kb | Distal (>10kb) Multiome | 824 | |
| chr15:90,839,491–90,840,162 | 95.6 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,883,883–90,884,953 | 50.9 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 32.6 kb | Distal (>10kb) Multiome | 817 | |
| chr15:90,931,729–90,933,077 | 3.4 kb | Proximal (<10kb) Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 44 bp | At TSS Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 19.6 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 21.5 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 59.4 kb | Distal (>10kb) Multiome | 929 | |
| chr15:91,021,873–91,022,829 | 87.2 kb | Distal (>10kb) Multiome | 735 | |
| chr15:91,032,872–91,033,463 | 97.9 kb | Distal (>10kb) Multiome | 347 | |
| chr15:91,099,400–91,100,613 | 164.9 kb | Distal (>10kb) Multiome | 351 | |
| chr15:91,101,202–91,101,847 | 166.2 kb | Distal (>10kb) Multiome | 48 | |
| chr15:91,140,477–91,140,966 | 205.5 kb | Distal (>10kb) Multiome | 31 | |
| chr15:91,202,218–91,202,996 | 267.4 kb | Distal (>10kb) Multiome | 29 | |
| chr15:92,647,486–92,648,715 | 1712.6 kb | Distal (>10kb) Multiome HiCAR | 186 |
Genomic view of the UNC45A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.