Enables ATPase binding activity. Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Part of endosome and protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBXN6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBXN6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBXN6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,782,866–2,783,778 | 1674.4 kb | Distal (>10kb) Multiome HiCAR | 998 | |
| chr19:2,784,850–2,785,981 | 1672.4 kb | Distal (>10kb) Multiome HiCAR | 682 | |
| chr19:4,182,102–4,182,890 | 275.2 kb | Distal (>10kb) Multiome | 862 | |
| chr19:4,198,066–4,198,600 | 259.5 kb | Distal (>10kb) Multiome | 214 | |
| chr19:4,246,623–4,247,617 | 210.5 kb | Distal (>10kb) Multiome | 960 | |
| chr19:4,326,625–4,329,107 | 129.3 kb | Distal (>10kb) Multiome | 567 | |
| chr19:4,342,323–4,344,016 | 114.9 kb | Distal (>10kb) Multiome | 969 | |
| chr19:4,390,525–4,391,068 | 67.1 kb | Distal (>10kb) Multiome | 464 | |
| chr19:4,399,835–4,401,019 | 57.2 kb | Distal (>10kb) Multiome | 828 | |
| chr19:4,402,106–4,403,050 | 55.3 kb | Distal (>10kb) Multiome | 731 | |
| chr19:4,456,541–4,458,172 | 34 bp | At TSS Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 14.2 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 16.9 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 77.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 98.9 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 124.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 140.4 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 175.7 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 178.6 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 181.6 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 212.6 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 221.4 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 266.2 kb | Distal (>10kb) Multiome | 1021 |
Genomic view of the UBXN6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.