Predicted to enable serine-type endopeptidase activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Acts upstream of or within protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for UBAC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBAC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBAC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:98,910,553–98,911,168 | 290.1 kb | Distal (>10kb) Multiome | 216 | |
| chr13:98,975,772–98,976,629 | 224.7 kb | Distal (>10kb) Multiome | 290 | |
| chr13:99,085,956–99,088,407 | 113.0 kb | Distal (>10kb) Multiome | 739 | |
| chr13:99,200,084–99,202,015 | 83 bp | At TSS Multiome | 952 | |
| chr13:99,204,975–99,205,472 | 4.4 kb | Proximal (<10kb) Multiome | 88 | |
| chr13:99,205,591–99,206,316 | 4.7 kb | Proximal (<10kb) | 41 | |
| chr13:99,307,801–99,308,401 | 107.2 kb | Distal (>10kb) Multiome | 300 | |
| chr13:99,498,126–99,499,495 | 297.8 kb | Distal (>10kb) Multiome | 771 |
Genomic view of the UBAC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.