The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TYRO3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TYRO3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TYRO3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:41,283,739–41,284,308 | 275.3 kb | Distal (>10kb) Multiome | 798 | |
| chr15:41,332,102–41,333,206 | 226.5 kb | Distal (>10kb) Multiome | 883 | |
| chr15:41,416,690–41,417,765 | 142.1 kb | Distal (>10kb) Multiome | 734 | |
| chr15:41,493,120–41,493,918 | 65.6 kb | Distal (>10kb) Multiome | 692 | |
| chr15:41,543,905–41,544,403 | 15.0 kb | Distal (>10kb) Multiome | 687 | |
| chr15:41,557,673–41,558,095 | 1.1 kb | Proximal (<10kb) | 420 | |
| chr15:41,558,746–41,559,337 | 69 bp | At TSS Multiome | 358 | |
| chr15:41,567,657–41,568,120 | 8.4 kb | Proximal (<10kb) | 98 | |
| chr15:41,568,267–41,568,742 | 9.0 kb | Proximal (<10kb) | 481 | |
| chr15:41,621,149–41,622,233 | 62.6 kb | Distal (>10kb) Multiome | 998 | |
| chr15:41,636,747–41,637,351 | 77.8 kb | Distal (>10kb) Multiome | 46 | |
| chr15:41,659,914–41,660,957 | 101.2 kb | Distal (>10kb) Multiome | 850 | |
| chr15:41,774,030–41,774,948 | 215.2 kb | Distal (>10kb) Multiome HiCAR | 944 | |
| chr15:41,827,735–41,828,567 | 268.8 kb | Distal (>10kb) Multiome HiCAR | 635 |
Genomic view of the TYRO3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.