This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]
Transcription factors with Perturb-seq knockdown data for TUBB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TUBB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TUBB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,466,230–30,466,713 | 253.8 kb | Distal (>10kb) Multiome | 369 | |
| chr6:30,489,117–30,490,512 | 230.0 kb | Distal (>10kb) Multiome | 750 | |
| chr6:30,516,006–30,516,707 | 204.0 kb | Distal (>10kb) Multiome | 739 | |
| chr6:30,555,407–30,557,765 | 163.7 kb | Distal (>10kb) Multiome | 1161 | |
| chr6:30,570,822–30,571,949 | 148.9 kb | Distal (>10kb) Multiome | 1000 | |
| chr6:30,614,393–30,615,939 | 105.2 kb | Distal (>10kb) Multiome | 837 | |
| chr6:30,616,770–30,618,155 | 102.8 kb | Distal (>10kb) Multiome | 1072 | |
| chr6:30,626,560–30,627,206 | 93.5 kb | Distal (>10kb) Multiome | 802 | |
| chr6:30,646,505–30,648,035 | 73.0 kb | Distal (>10kb) Multiome | 961 | |
| chr6:30,672,571–30,673,266 | 47.4 kb | Distal (>10kb) Multiome HiCAR | 812 | |
| chr6:30,679,032–30,679,479 | 41.2 kb | Distal (>10kb) Multiome HiCAR | 603 | |
| chr6:30,686,268–30,688,032 | 33.1 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr6:30,690,445–30,691,240 | 29.4 kb | Distal (>10kb) Multiome | 644 | |
| chr6:30,716,986–30,717,874 | 2.9 kb | Proximal (<10kb) Multiome | 1059 | |
| chr6:30,719,428–30,720,577 | 167 bp | At TSS Multiome | 724 | |
| chr6:30,720,820–30,721,086 | 469 bp | At TSS | 500 | |
| chr6:30,721,307–30,722,103 | 1.2 kb | Proximal (<10kb) Multiome | 872 | |
| chr6:30,722,280–30,722,892 | 1.9 kb | Proximal (<10kb) | 533 | |
| chr6:30,725,731–30,726,564 | 5.8 kb | Proximal (<10kb) Multiome | 478 | |
| chr6:30,740,996–30,745,094 | 22.4 kb | Distal (>10kb) Multiome | 1233 | |
| chr6:30,763,647–30,765,193 | 44.1 kb | Distal (>10kb) Multiome | 850 | |
| chr6:30,880,638–30,881,295 | 160.6 kb | Distal (>10kb) Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 162.5 kb | Distal (>10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 164.0 kb | Distal (>10kb) Multiome | 538 | |
| chr6:30,907,770–30,908,494 | 187.7 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 193.9 kb | Distal (>10kb) Multiome | 944 | |
| chr6:30,942,475–30,943,087 | 222.5 kb | Distal (>10kb) Multiome | 300 | |
| chr6:30,955,192–30,955,975 | 235.4 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the TUBB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.