Involved in axonemal dynein complex assembly and sperm axoneme assembly. Located in several cellular components, including centrosome; cytosol; and nuclear membrane. Implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TTC12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TTC12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TTC12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:112,289,677–112,290,832 | 1024.4 kb | Distal (>10kb) Multiome HiCAR | 568 | |
| chr11:113,093,473–113,094,494 | 220.6 kb | Distal (>10kb) Multiome | 118 | |
| chr11:113,192,132–113,192,786 | 122.1 kb | Distal (>10kb) Multiome | 88 | |
| chr11:113,240,569–113,241,253 | 73.6 kb | Distal (>10kb) Multiome | 76 | |
| chr11:113,273,470–113,274,284 | 40.6 kb | Distal (>10kb) Multiome | 55 | |
| chr11:113,305,786–113,305,995 | 8.6 kb | Proximal (<10kb) | 238 | |
| chr11:113,314,281–113,315,117 | 18 bp | At TSS Multiome | 715 | |
| chr11:113,369,396–113,370,492 | 55.1 kb | Distal (>10kb) Multiome | 121 | |
| chr11:113,387,594–113,388,276 | 73.3 kb | Distal (>10kb) Multiome HiCAR | 217 | |
| chr11:113,389,169–113,390,063 | 75.0 kb | Distal (>10kb) Multiome HiCAR | 64 | |
| chr11:113,429,233–113,430,106 | 115.0 kb | Distal (>10kb) Multiome | 143 | |
| chr11:113,474,175–113,475,764 | 159.9 kb | Distal (>10kb) Multiome HiCAR | 487 | |
| chr11:113,681,336–113,682,352 | 367.0 kb | Distal (>10kb) Multiome HiCAR | 213 | |
| chr11:113,773,177–113,774,192 | 459.2 kb | Distal (>10kb) Multiome HiCAR | 794 |
Genomic view of the TTC12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.