Predicted to enable transforming growth factor beta binding activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and nervous system development. Predicted to act upstream of or within several processes, including ciliary body morphogenesis; negative regulation of Wnt signaling pathway; and telencephalon development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TSKU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSKU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSKU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:76,554,474–76,555,062 | 229.4 kb | Distal (>10kb) Multiome | 45 | |
| chr11:76,624,568–76,625,315 | 159.1 kb | Distal (>10kb) Multiome | 105 | |
| chr11:76,670,486–76,671,227 | 113.3 kb | Distal (>10kb) Multiome | 303 | |
| chr11:76,733,962–76,736,172 | 50.0 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr11:76,758,769–76,759,574 | 24.9 kb | Distal (>10kb) Multiome | 99 | |
| chr11:76,770,356–76,771,447 | 13.3 kb | Distal (>10kb) Multiome | 371 | |
| chr11:76,781,571–76,782,180 | 1.2 kb | Proximal (<10kb) | 189 | |
| chr11:76,782,794–76,784,887 | 63 bp | At TSS Multiome | 929 | |
| chr11:76,785,535–76,785,870 | 2.2 kb | Proximal (<10kb) | 52 | |
| chr11:76,787,865–76,789,130 | 4.4 kb | Proximal (<10kb) Multiome | 462 | |
| chr11:76,793,114–76,793,711 | 9.8 kb | Proximal (<10kb) | 181 | |
| chr11:76,798,746–76,799,610 | 15.2 kb | Distal (>10kb) Multiome | 661 | |
| chr11:76,807,112–76,807,736 | 23.4 kb | Distal (>10kb) Multiome | 373 | |
| chr11:76,860,430–76,861,513 | 76.7 kb | Distal (>10kb) Multiome | 706 | |
| chr11:77,039,527–77,040,269 | 255.7 kb | Distal (>10kb) Multiome | 214 | |
| chr11:77,066,090–77,067,711 | 282.7 kb | Distal (>10kb) Multiome | 664 |
Genomic view of the TSKU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.