This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for TSEN15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSEN15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSEN15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:183,830,999–183,831,540 | 220.4 kb | Distal (>10kb) Multiome | 46 | |
| chr1:183,996,117–183,996,814 | 55.0 kb | Distal (>10kb) Multiome | 312 | |
| chr1:184,035,887–184,037,826 | 14.2 kb | Distal (>10kb) Multiome | 800 | |
| chr1:184,047,508–184,048,144 | 3.5 kb | Proximal (<10kb) | 135 | |
| chr1:184,051,218–184,052,235 | 187 bp | At TSS Multiome | 1022 | |
| chr1:184,156,878–184,157,773 | 105.7 kb | Distal (>10kb) Multiome | 202 | |
| chr1:184,190,240–184,191,549 | 139.3 kb | Distal (>10kb) Multiome | 214 | |
| chr1:184,242,238–184,242,897 | 190.9 kb | Distal (>10kb) Multiome | 250 | |
| chr1:184,244,558–184,245,746 | 193.6 kb | Distal (>10kb) Multiome | 42 | |
| chr1:184,313,571–184,314,257 | 262.2 kb | Distal (>10kb) Multiome | 94 | |
| chr1:184,350,363–184,350,931 | 299.1 kb | Distal (>10kb) Multiome | 97 | |
| chr1:184,582,004–184,583,178 | 530.8 kb | Distal (>10kb) Multiome HiCAR | 114 | |
| chr1:184,663,783–184,664,949 | 612.5 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr1:184,695,922–184,696,742 | 644.7 kb | Distal (>10kb) Multiome HiCAR | 40 |
Genomic view of the TSEN15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.