The protein encoded by this gene is a putative tRNA methyltransferase found in the cytoplasm. Defects in this gene may be a cause of partial epilepsy with pericentral spikes (PEPS), but that has not been proven definitively. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for TRMT44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:8,157,851–8,159,668 | 281.9 kb | Distal (>10kb) Multiome | 635 | |
| chr4:8,242,133–8,242,751 | 198.4 kb | Distal (>10kb) Multiome HiCAR | 482 | |
| chr4:8,269,411–8,270,406 | 171.0 kb | Distal (>10kb) Multiome | 248 | |
| chr4:8,410,587–8,411,261 | 29.9 kb | Distal (>10kb) Multiome | 239 | |
| chr4:8,427,739–8,429,898 | 11.2 kb | Distal (>10kb) Multiome | 796 | |
| chr4:8,430,194–8,430,421 | 5.7 kb | Proximal (<10kb) | 14 | |
| chr4:8,435,765–8,436,370 | 4.8 kb | Proximal (<10kb) Multiome | 58 | |
| chr4:8,437,244–8,438,165 | 3.0 kb | Proximal (<10kb) Multiome | 79 | |
| chr4:8,440,272–8,441,421 | 22 bp | At TSS Multiome | 843 | |
| chr4:8,559,567–8,561,304 | 119.1 kb | Distal (>10kb) Multiome HiCAR | 152 | |
| chr4:8,567,886–8,568,408 | 127.4 kb | Distal (>10kb) Multiome | 46 | |
| chr4:8,580,009–8,581,204 | 139.8 kb | Distal (>10kb) Multiome HiCAR | 591 | |
| chr4:8,592,223–8,593,386 | 151.9 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr4:8,607,476–8,608,065 | 167.0 kb | Distal (>10kb) Multiome HiCAR | 216 |
Genomic view of the TRMT44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.