This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for TRMT10C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRMT10C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRMT10C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:101,466,683–101,467,491 | 94.7 kb | Distal (>10kb) Multiome | 289 | |
| chr3:101,512,475–101,513,632 | 48.8 kb | Distal (>10kb) Multiome | 799 | |
| chr3:101,530,192–101,530,904 | 31.3 kb | Distal (>10kb) Multiome | 336 | |
| chr3:101,553,463–101,553,683 | 8.2 kb | Proximal (<10kb) | 11 | |
| chr3:101,556,160–101,556,330 | 5.5 kb | Proximal (<10kb) | 6 | |
| chr3:101,559,655–101,559,971 | 1.9 kb | Proximal (<10kb) | 32 | |
| chr3:101,561,343–101,562,162 | 14 bp | At TSS Multiome | 783 | |
| chr3:101,562,320–101,562,667 | 453 bp | At TSS | 111 | |
| chr3:101,573,305–101,575,121 | 12.2 kb | Distal (>10kb) Multiome | 1039 | |
| chr3:101,641,500–101,642,206 | 79.9 kb | Distal (>10kb) Multiome | 397 | |
| chr3:101,724,220–101,725,851 | 162.9 kb | Distal (>10kb) Multiome | 749 | |
| chr3:101,778,676–101,779,992 | 217.4 kb | Distal (>10kb) Multiome | 826 | |
| chr3:101,848,739–101,850,257 | 287.5 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the TRMT10C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.