The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Transcription factors with Perturb-seq knockdown data for TRIM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRIM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRIM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,935,635–152,938,175 | 268.2 kb | Distal (>10kb) Multiome | 620 | |
| chr4:152,956,599–152,958,298 | 246.6 kb | Distal (>10kb) Multiome | 369 | |
| chr4:153,083,338–153,083,974 | 120.8 kb | Distal (>10kb) Multiome | 317 | |
| chr4:153,125,863–153,126,388 | 78.3 kb | Distal (>10kb) Multiome | 64 | |
| chr4:153,152,013–153,153,918 | 50.9 kb | Distal (>10kb) Multiome HiCAR | 646 | |
| chr4:153,204,222–153,207,340 | 1.4 kb | Proximal (<10kb) Multiome | 625 | |
| chr4:153,207,659–153,207,851 | 3.2 kb | Proximal (<10kb) | 85 | |
| chr4:153,209,099–153,209,950 | 4.7 kb | Proximal (<10kb) | 254 | |
| chr4:153,222,243–153,223,345 | 18.2 kb | Distal (>10kb) Multiome | 755 | |
| chr4:153,248,554–153,249,897 | 44.9 kb | Distal (>10kb) Multiome | 489 | |
| chr4:153,344,063–153,345,542 | 140.2 kb | Distal (>10kb) Multiome | 920 | |
| chr4:153,452,038–153,452,864 | 247.9 kb | Distal (>10kb) Multiome | 245 | |
| chr4:153,465,572–153,467,737 | 261.9 kb | Distal (>10kb) Multiome | 862 |
Genomic view of the TRIM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.