Involved in Golgi organization and collagen biosynthetic process. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRAPPC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:31,684,202–31,686,118 | 257.8 kb | Distal (>10kb) Multiome | 718 | |
| chr18:31,825,470–31,827,414 | 116.3 kb | Distal (>10kb) Multiome | 319 | |
| chr18:31,942,190–31,943,930 | 108 bp | At TSS Multiome | 1005 | |
| chr18:31,944,232–31,944,894 | 1.1 kb | Proximal (<10kb) | 88 | |
| chr18:31,946,388–31,947,273 | 3.7 kb | Proximal (<10kb) Multiome | 158 | |
| chr18:31,950,397–31,950,840 | 7.3 kb | Proximal (<10kb) | 29 | |
| chr18:31,951,815–31,952,102 | 8.7 kb | Proximal (<10kb) | 7 | |
| chr18:32,018,028–32,020,301 | 75.3 kb | Distal (>10kb) Multiome | 961 | |
| chr18:32,022,264–32,023,296 | 79.7 kb | Distal (>10kb) Multiome | 94 | |
| chr18:32,091,522–32,093,539 | 149.4 kb | Distal (>10kb) Multiome | 1047 | |
| chr18:32,157,719–32,158,676 | 215.1 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the TRAPPC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.