The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Transcription factors with Perturb-seq knockdown data for TPST2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPST2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPST2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:24,592,399–24,593,422 | 1997.1 kb | Distal (>10kb) Multiome HiCAR | 650 | |
| chr22:26,428,616–26,429,779 | 160.9 kb | Distal (>10kb) Multiome | 481 | |
| chr22:26,483,346–26,484,220 | 106.3 kb | Distal (>10kb) Multiome | 895 | |
| chr22:26,512,193–26,512,760 | 77.6 kb | Distal (>10kb) Multiome | 692 | |
| chr22:26,588,940–26,590,564 | 8 bp | At TSS Multiome | 545 | |
| chr22:26,632,639–26,633,120 | 42.7 kb | Distal (>10kb) Multiome | 225 | |
| chr22:26,644,963–26,645,832 | 55.3 kb | Distal (>10kb) Multiome | 522 | |
| chr22:26,658,631–26,659,207 | 68.8 kb | Distal (>10kb) Multiome | 485 | |
| chr22:26,672,265–26,673,339 | 82.7 kb | Distal (>10kb) Multiome | 604 | |
| chr22:26,837,981–26,838,718 | 248.3 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the TPST2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.