Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TPRKB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPRKB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPRKB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:73,707,107–73,707,579 | 30.1 kb | Distal (>10kb) Multiome | 38 | |
| chr2:73,736,841–73,737,678 | 63 bp | At TSS Multiome | 952 | |
| chr2:73,779,673–73,780,474 | 42.8 kb | Distal (>10kb) Multiome | 767 | |
| chr2:73,828,734–73,829,492 | 91.6 kb | Distal (>10kb) Multiome | 774 | |
| chr2:73,921,096–73,921,666 | 184.0 kb | Distal (>10kb) Multiome | 284 | |
| chr2:73,926,648–73,927,193 | 189.5 kb | Distal (>10kb) Multiome | 961 | |
| chr2:73,981,145–73,981,910 | 244.2 kb | Distal (>10kb) Multiome | 483 | |
| chr2:73,983,451–73,985,871 | 248.0 kb | Distal (>10kb) Multiome | 821 | |
| chr2:74,002,059–74,003,348 | 265.3 kb | Distal (>10kb) Multiome | 514 | |
| chr2:74,008,705–74,009,321 | 271.6 kb | Distal (>10kb) Multiome | 142 | |
| chr2:74,026,198–74,026,578 | 289.1 kb | Distal (>10kb) Multiome | 88 |
Genomic view of the TPRKB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.