Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for TNIK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNIK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNIK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:171,370,865–171,371,724 | 89.2 kb | Distal (>10kb) Multiome | 98 | |
| chr3:171,410,043–171,410,635 | 50.0 kb | Distal (>10kb) Multiome | 94 | |
| chr3:171,427,903–171,428,911 | 31.9 kb | Distal (>10kb) Multiome | 311 | |
| chr3:171,453,324–171,453,763 | 6.6 kb | Proximal (<10kb) | 178 | |
| chr3:171,457,710–171,458,408 | 2.0 kb | Proximal (<10kb) | 139 | |
| chr3:171,458,887–171,461,331 | 148 bp | At TSS Multiome | 725 | |
| chr3:171,462,345–171,462,526 | 1.9 kb | Proximal (<10kb) | 92 |
Genomic view of the TNIK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.