This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFAIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFAIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFAIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,040,846–28,042,232 | 294.3 kb | Distal (>10kb) Multiome | 682 | |
| chr17:28,227,184–28,228,835 | 108.1 kb | Distal (>10kb) Multiome | 426 | |
| chr17:28,251,169–28,251,939 | 84.2 kb | Distal (>10kb) Multiome | 480 | |
| chr17:28,317,975–28,319,646 | 16.7 kb | Distal (>10kb) Multiome | 858 | |
| chr17:28,321,010–28,321,937 | 14.3 kb | Distal (>10kb) Multiome | 25 | |
| chr17:28,335,024–28,336,772 | 141 bp | At TSS Multiome | 933 | |
| chr17:28,357,059–28,357,929 | 21.8 kb | Distal (>10kb) Multiome | 878 | |
| chr17:28,371,118–28,372,519 | 35.8 kb | Distal (>10kb) Multiome | 532 | |
| chr17:28,381,316–28,381,844 | 45.8 kb | Distal (>10kb) Multiome | 159 | |
| chr17:28,405,673–28,406,384 | 70.2 kb | Distal (>10kb) Multiome | 591 | |
| chr17:28,466,531–28,467,034 | 131.0 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 216.9 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 235.8 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 241.2 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 263.4 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 286.6 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the TNFAIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.