Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM263. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM263 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM263, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:106,247,023–106,248,967 | 707.7 kb | Distal (>10kb) Multiome HiCAR | 593 | |
| chr12:106,357,226–106,358,686 | 597.9 kb | Distal (>10kb) Multiome HiCAR | 1122 | |
| chr12:106,773,771–106,775,183 | 181.5 kb | Distal (>10kb) Multiome | 953 | |
| chr12:106,903,307–106,903,916 | 52.1 kb | Distal (>10kb) Multiome | 193 | |
| chr12:106,954,854–106,956,979 | 117 bp | At TSS Multiome | 927 | |
| chr12:106,986,640–106,987,674 | 31.3 kb | Distal (>10kb) Multiome | 764 | |
| chr12:107,092,776–107,094,398 | 137.9 kb | Distal (>10kb) Multiome | 884 | |
| chr12:107,122,282–107,122,891 | 166.8 kb | Distal (>10kb) Multiome | 88 |
Genomic view of the TMEM263 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.