Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM161B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM161B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM161B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,140,327–88,142,256 | 127.4 kb | Distal (>10kb) Multiome | 616 | |
| chr5:88,258,737–88,259,157 | 9.7 kb | Proximal (<10kb) | 6 | |
| chr5:88,268,309–88,269,790 | 82 bp | At TSS Multiome | 803 | |
| chr5:88,659,646–88,661,615 | 392.3 kb | Distal (>10kb) Multiome HiCAR | 570 | |
| chr5:88,674,048–88,676,457 | 407.2 kb | Distal (>10kb) Multiome HiCAR | 679 |
Genomic view of the TMEM161B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.