This gene encodes a tight junction-associated protein. Incorporation of the encoded protein into tight junctions occurs at a late stage of formation of the junctions. The encoded protein localizes to the Golgi and may function in vesicle trafficking. Alternatively spliced transcript variants have been described. A related pseudogene exists on the X chromosome. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for TJAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TJAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TJAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,181,838–43,182,555 | 295.4 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,228,982–43,229,794 | 248.1 kb | Distal (>10kb) Multiome | 918 | |
| chr6:43,246,576–43,247,616 | 230.4 kb | Distal (>10kb) Multiome | 750 | |
| chr6:43,267,244–43,268,167 | 209.9 kb | Distal (>10kb) Multiome HiCAR | 772 | |
| chr6:43,285,054–43,285,508 | 192.2 kb | Distal (>10kb) Multiome | 68 | |
| chr6:43,308,219–43,309,149 | 168.7 kb | Distal (>10kb) Multiome | 462 | |
| chr6:43,368,714–43,370,143 | 107.9 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 49.9 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 22.8 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,469,183–43,469,538 | 8.0 kb | Proximal (<10kb) | 71 | |
| chr6:43,477,347–43,478,043 | 7 bp | At TSS Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 29.3 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 32.8 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 39.4 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 98.5 kb | Distal (>10kb) Multiome | 1044 | |
| chr6:43,628,488–43,630,447 | 152.6 kb | Distal (>10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 158.2 kb | Distal (>10kb) Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 167.8 kb | Distal (>10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 189.8 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 190.9 kb | Distal (>10kb) Multiome | 664 | |
| chr6:43,695,239–43,695,940 | 218.1 kb | Distal (>10kb) Multiome | 207 | |
| chr6:43,702,335–43,703,403 | 225.4 kb | Distal (>10kb) Multiome | 713 | |
| chr6:43,706,840–43,708,370 | 230.4 kb | Distal (>10kb) Multiome | 307 | |
| chr6:43,739,421–43,740,065 | 262.2 kb | Distal (>10kb) Multiome | 175 | |
| chr6:43,769,188–43,772,162 | 292.4 kb | Distal (>10kb) Multiome | 1112 | |
| chr6:43,774,651–43,775,250 | 297.4 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the TJAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.