TIMM22
translocase of inner mitochondrial membrane 22 | TIM22, TEX4

Multipass transmembrane proteins are brought into mitochondria and inserted into the mitochondrial inner membrane by way of the TIM22 complex. This complex has six subunits and is a twin-pore translocase. The protein encoded by this gene is a subunit of TIM22 and represents the voltage-activated and signal-gated channel. [provided by RefSeq, Jul 2016]

Member of: DE-1 DE-1.56 Developmental clusters: GC5
Biological processes 18 terms
TIM22 mitochondrial import inner membrane insertion complex (GO:0042721)TIM22 mitochondrial import inner membrane insertion complex (GO:0042721)TIM22 mitochondrial import inner membrane insertion complex (GO:0042721)membrane insertase activity (GO:0032977)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion targeting sequence binding (GO:0030943)protein binding (GO:0005515)protein insertion into mitochondrial inner membrane (GO:0045039)protein insertion into mitochondrial inner membrane (GO:0045039)protein insertion into mitochondrial inner membrane (GO:0045039)protein insertion into mitochondrial inner membrane (GO:0045039)protein insertion into mitochondrial inner membrane (GO:0045039)protein transmembrane transport (GO:0071806)transmembrane protein transporter activity (GO:0008320)transmembrane protein transporter activity (GO:0008320)
Expression (TPM)
TIMM22 — as a Regulated Gene

TFs regulating TIMM22 0 TFs

Transcription factors with Perturb-seq knockdown data for TIMM22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TIMM22

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:409,399–411,454 586.9 kb Distal (>10kb) Multiome HiCAR 665
chr17:714,554–715,298 282.2 kb Distal (>10kb) Multiome 798
chr17:731,870–733,144 264.7 kb Distal (>10kb) Multiome HiCAR 602
chr17:751,539–752,928 244.8 kb Distal (>10kb) Multiome HiCAR 891
chr17:781,922–782,799 214.8 kb Distal (>10kb) Multiome HiCAR 914
chr17:875,256–875,758 121.6 kb Distal (>10kb) Multiome 42
chr17:927,652–928,423 69.2 kb Distal (>10kb) Multiome 315
chr17:933,255–933,971 63.5 kb Distal (>10kb) Multiome 400
chr17:951,413–952,178 45.4 kb Distal (>10kb) Multiome 385
chr17:964,907–965,931 31.5 kb Distal (>10kb) Multiome 256
chr17:978,189–980,530 17.3 kb Distal (>10kb) Multiome 639
chr17:996,479–997,532 288 bp At TSS Multiome 994
chr17:1,031,608–1,032,193 34.8 kb Distal (>10kb) Multiome 54
chr17:1,109,073–1,109,822 112.4 kb Distal (>10kb) Multiome 401
chr17:1,179,265–1,180,687 182.9 kb Distal (>10kb) Multiome 303
chr17:1,187,041–1,187,512 190.2 kb Distal (>10kb) Multiome 361
chr17:1,202,976–1,204,162 206.3 kb Distal (>10kb) Multiome 420
chr17:1,210,129–1,211,219 213.6 kb Distal (>10kb) Multiome 35
chr17:1,268,002–1,268,635 271.2 kb Distal (>10kb) Multiome 644

Genome Browser

Genomic view of the TIMM22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:399,399 – 1,278,635
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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