The protein encoded by this gene is necessary for intercellular bridges in germ cells, which are required for spermatogenesis. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for TEX14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:58,324,153–58,325,169 | 239.7 kb | Distal (>10kb) Multiome | 274 | |
| chr17:58,338,012–58,338,430 | 226.1 kb | Distal (>10kb) Multiome | 559 | |
| chr17:58,339,009–58,339,515 | 225.0 kb | Distal (>10kb) Multiome | 382 | |
| chr17:58,351,751–58,352,762 | 211.9 kb | Distal (>10kb) Multiome | 990 | |
| chr17:58,487,466–58,488,518 | 76.5 kb | Distal (>10kb) Multiome | 222 | |
| chr17:58,513,911–58,515,157 | 49.6 kb | Distal (>10kb) Multiome | 585 | |
| chr17:58,517,239–58,519,377 | 46.2 kb | Distal (>10kb) Multiome | 1140 | |
| chr17:58,527,884–58,528,411 | 36.1 kb | Distal (>10kb) Multiome | 79 | |
| chr17:58,531,392–58,532,430 | 32.2 kb | Distal (>10kb) Multiome | 323 | |
| chr17:58,572,967–58,573,214 | 8.7 kb | Proximal (<10kb) | 69 | |
| chr17:58,630,482–58,632,252 | 67.5 kb | Distal (>10kb) Multiome | 1257 | |
| chr17:58,657,864–58,659,830 | 94.9 kb | Distal (>10kb) Multiome | 1269 | |
| chr17:58,669,900–58,670,548 | 106.0 kb | Distal (>10kb) Multiome | 52 | |
| chr17:58,678,911–58,679,743 | 115.3 kb | Distal (>10kb) Multiome | 889 | |
| chr17:58,692,284–58,692,956 | 128.4 kb | Distal (>10kb) Multiome | 1038 | |
| chr17:58,755,487–58,756,995 | 191.6 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the TEX14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.