TET3

tet methylcytosine dioxygenase 3 | MGC22014, hCG_40738

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; methyl-CpG binding activity; and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein O-linked glycosylation. Predicted to be located in cytoplasm and male pronucleus. Predicted to be active in nucleus. Biomarker of esophagus squamous cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2 DE-2.1

Biological processes 26 terms

2-oxoglutarate-dependent dioxygenase activity (GO:0016706)DNA 5-methylcytosine dioxygenase activity (GO:0070579)DNA 5-methylcytosine dioxygenase activity (GO:0070579)DNA 5-methylcytosine dioxygenase activity (GO:0070579)DNA binding (GO:0003677)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromosome (GO:0005694)cytoplasm (GO:0005737)cytoplasm (GO:0005737)epigenetic programing of male pronucleus (GO:0044727)epigenetic programing of male pronucleus (GO:0044727)epigenetic regulation of gene expression (GO:0040029)female pronucleus (GO:0001939)male pronucleus (GO:0001940)male pronucleus (GO:0001940)methyl-CpG binding (GO:0008327)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of gene expression via chromosomal CpG island demethylation (GO:0044029)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein O-linked glycosylation (GO:0006493)protein binding (GO:0005515)regulation of gene expression (GO:0010468)zinc ion binding (GO:0008270)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating TET3 0 TFs

Transcription factors with Perturb-seq knockdown data for TET3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TET3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TET3

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TET3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:73,707,107–73,707,579	277.6 kb	Distal (>10kb) Multiome	38
chr2:73,736,841–73,737,678	247.5 kb	Distal (>10kb) Multiome	952
chr2:73,779,673–73,780,474	204.8 kb	Distal (>10kb) Multiome	767
chr2:73,828,734–73,829,492	155.9 kb	Distal (>10kb) Multiome	774
chr2:73,921,096–73,921,666	63.5 kb	Distal (>10kb) Multiome	284
chr2:73,926,648–73,927,193	58.0 kb	Distal (>10kb) Multiome	961
chr2:73,981,145–73,981,910	3.3 kb	Proximal (<10kb) Multiome	483
chr2:73,983,451–73,985,871	423 bp	At TSS Multiome	821
chr2:74,002,059–74,003,348	17.8 kb	Distal (>10kb) Multiome	514
chr2:74,006,582–74,006,876	3.9 kb	Proximal (<10kb)	30
chr2:74,008,705–74,009,321	24.1 kb	Distal (>10kb) Multiome	142
chr2:74,026,198–74,026,578	41.5 kb	Distal (>10kb) Multiome	88
chr2:74,119,987–74,120,643	135.5 kb	Distal (>10kb) Multiome	969
chr2:74,147,573–74,148,843	163.1 kb	Distal (>10kb) Multiome HiCAR	884
chr2:74,178,147–74,179,324	194.0 kb	Distal (>10kb) Multiome	869
chr2:74,187,993–74,188,519	203.3 kb	Distal (>10kb) Multiome	192
chr2:74,198,074–74,199,486	213.6 kb	Distal (>10kb) Multiome	1098
chr2:74,261,293–74,261,813	276.7 kb	Distal (>10kb) Multiome	184

Genome Browser

Genomic view of the TET3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.